Biosintesis A6'7-AnhidroeritromisinMelalui Penghambatan Reduksi Enoil Oleh Isoniazid Pada FERMENTASI Saccharopolyspora erythraea ATCC 11635
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2003
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/27189/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=10241 |
Daftar Isi:
- ABSTRACT The biosynthesis of new erythromycin derivative has been carried out by adding of isoniazid (INH) into fermentation of Saccharopolyspora erythraea ATCC 11635. INH was added to inhibit the enoyl-reduction process in the fourth step of 6- deoxyerythronolid B (6-DEB) biosynthesis, so in the last process was expected to produce Av-anhydroerythromycin which more stable in acidic condition than erythromycin. The isolating new metabolites: A-KG was obtained from the shake fermentation with additional INH