Uji laboratorium pada aids
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 1992
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/24911/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=7889 |
Daftar Isi:
- ABSTRAK Most of HIV infected individuals are asymptomatic or show non-specific symptoms in the early phase. Diagnosis relies entirely on laboratory tests. Many tests, either antibody or antigen tests have been developed with high sensitivity and specificity. Antibody tests, i.e. EL1SAs screening confirmed by Western blotting are the conventional approach of HIV infection diagnosis. These tests are very expensive, time consuming and technically demanding. Other approaches that are easier, cheaper and more suitable for field practice have been tried out with high sensitivity and specificity. Antigen tests are still difficult to implement. High titer of p24 antigen in the early phase means bad prognosis. CD4+ lymphocyte count, anti-p24 antibody and p24 antigen titer are essential for monitoring the progression of the disease and the success of treatment. The progression of HIV infection to clinical AIDS is accompanied by decreasing CD4+ lymphocyte count and increasing p24 antigenemia, while anti-p24 antibody is decreasing. In the successful treatment the reverse situation is noted. To prevent the spread of HIV infection any HIV, infected individual should be detected: laboratory investigation should be done on individuals at risk, e.g. drug abusers, homosexuals, individual with multiple sexual partners, individual with HIV-infected partner(s), babies of seropositive mothers. Notification of sexual partners and anonymous testing can reveal the epidemiology of HIV in the related population. Prenatal testing is important, considering that anti-retroviral agents available now can probalby reduce the vertical transmission. Testing of blood and blood products is imperative to control the spread of HIV infection by the route of transfusion. Key words : ELISA, Western blot, CD4+ lymphocyte, disease progression