Imunologi Aids
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 1992
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/24843/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=7821 |
Daftar Isi:
- ABSTRAK AIDS is caused by infection of HIV with manifestation of immune deficiency syndrome. Virus protein antigen env gp120 tends to bind CD4 molecules express on Th cells, monocy tes and other CD4-cells. It has been shown that Th cells dominantly suffered from infect-ion since CD4 molecules express mostly on Th cells. The virus has the capability to destroy the CD4' cells (cytopha tic) since Th cells is the central regulator of immune respons of the body, that many cells correlated to immune system will also be affected such as B cells, NK cells and other T cell subpopulations. The most characteristic feature is the decrease number and function of CD4 helper/inducer T lymphocytes. Patients with HIV infection also have abnormalities in the number and activity of CDS suppressor /cytotoxic T lymphocytes, defective soluble antigen recognition, polyclonal B cell activation and decreased cytotoxicity. The CD4 cell defect is the most critical abnormality in the immwiopa thogenesis of HIV. Key Words : AIDS, HIV, gp 120, CD4- Th, immune regulation