Sintesis Kurkumin dan Pengaruhnya Terhadap Farmakokinetika Teofilin Pada Tikus
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2003
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/20036/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=2878 |
Daftar Isi:
- ABSTRACT The research was aimed to observe curcumin activity to theophylline pharmacokinetics in rats. This research was initiated by performing synthesis of curcumin. The purity test of synthesized compound included a melting range test, thin layer chromatography and structure elucidation was done using spectrophotometer UV-VIS, spectrometer IR and JH-NMR. The study of interaction curcumin with theophylline pharmacokinetic was conducted employing a completely fandomaized design using male Wistar rats which were divided into 5 groups (6 rats for each group). The groups were given a single oral theophylline 25 mg/kg BW as a control group and were confered single oral curcumin 2, 5, 10 and 40 mg/kg BW each dose 4 hours before treatment with teophylline. Serial blood samples(0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged theophylline in blood. The concentration of theophylline was determined based on a standard curve and from the concentration to time data was determined theophylline pharmacokinetics i.e. Ka, C] AUC0 di Vdss, t1/2 elimination, Cl, and MRT. The results indicated that the synthesized curcumin has chemical structure in accordance with those estimated. Curcumin was found to be able to decrease theophylline clearance 44-63% (P