Ketersediaan hayati relatif furosemida dalam bentuk dispersi padat =Comparative Bio availability Furosemide in Solid Dispersion Forms
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2001
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/19677/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=2510 |
Daftar Isi:
- ABSTRACT Solid dispersion system of water-insoluble furosemide in polyvinylpirolidon (PVP) was prepared by a solvent method in various ratios of 1 : 5 and 1 : 7 of the drug and PVP, respectively in order to improve furosemide bioavailability. The bioavailability of furosemide - PVP solid dispersion was compared with pure furosemide (control) and Lasix® (reference). The study was done in a cross over design with a single-dose peroral that administered to the white male rabbits (n = 6). Furosemide blood levels were determined spectrofluorometrically by an extraction method. The area under the blood concentration-time curve AUC0 y peak blood concentration Cmax and time to reach peak blood concentration Tmax were used to compare their bioavailabilities. The solid dispersion systems produced a higher extent of bioavailability than pure furosemide (P < 0,05). On the contrary, no statistically significant difference the extent of bioavailability between solid dispersion and Lasix® (P > 0,05). Finally, furosemide - PVP solid dispersion (1: 7) was the best formulation with the highest extent of bioavailability and bioequivalence with the Lasix® formula's. Keywords: solid dispersion - solubility - dissolution - bioavailability -furosemide.