Pengaruh dosis metronidazol dan praperlakuan rifampisin terhadap kinetika eliminasi metronidazol pada sukarelawan sehat = The Effects of Doses and Pre-treatment with Rifampicin on the Elimination Kinetics of Metronidazol
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 1991
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/18100/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=878 |
Daftar Isi:
- Metronidazole is a widely used antimicrobial, mainly sliminated by microsomal oxidation the liver (Loft et al., 1986). Interactions with other drugs affecting the hepatic drug metabolism, therefore can be anticipated. This study was designed to investigate the effects of doses and pre-treatment with rifampicin on the elimination kine tics of metronidazole. The result showe that after 1000 mg dose, there was slight (9,9%) but statistically significant (p < 0,05) reduction of metronidazole clearance compared to that after 500 mg, indicating the existence of dose-dependent elimination kinetics. Pretreatment with rifampicin accelerates the elimination of metronidazole clearance (45-50%), either after 600 mg or 1000 mg doses of metronidazole. In summary, the elimination kinetics of metronidasole appear to be dose-dependent, but not likely to be of clinical importance. Pretreatment with rifampicin significantly and substantially accelerates metronidazole elimination and most likely to be of clinical importance. Keywords: metronidazole rifampicin -- drug interaction