Synthesis of new activated indoles
| Main Author: | Perpustakaan UGM, i-lib |
|---|---|
| Format: | Article NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2004
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/17732/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=495 |
Daftar Isi:
- 344=Bromopheny1)-4,6-dimethoxy-2-methylindole has been synthesized from 4, 6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclization of amido ketone was performed by trifluoroacetic acid and subsequent deprotection with potassium hydroxide in methanol afforded a white solid of 3(4'-bromopheny0-4,6-dimethoxy-2-methylindole in 86%. Keywords: 4, 6-dimethoxyaniline, 2-methylindole, Bischler method