HUBUNGAN KADAR CA-125 PRAOPERATIF TERHADAP PROGNOSIS SURVIVAL PENDERITA KANKER OVARIUM EPITELIAL DI RSUP DR. SARDJITO
| Main Authors: | , HERLINA PRAJATMO, , Dr. dr. H. Heru Pradjatmo, M.Kes, SpOG(K) |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/134493/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=77142 |
| ctrlnum |
134493 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>https://repository.ugm.ac.id/134493/</relation><title>HUBUNGAN KADAR CA-125 PRAOPERATIF TERHADAP PROGNOSIS SURVIVAL PENDERITA KANKER OVARIUM EPITELIAL DI RSUP DR. SARDJITO</title><creator>, HERLINA PRAJATMO</creator><creator>, Dr. dr. H. Heru Pradjatmo, M.Kes, SpOG(K)</creator><subject>ETD</subject><description>Background: CA-125 level increases in 50% of patients with stage I, 90% of patients with stage
II, 92% of patients with stage III and 94% of patients with stage IV ovarian cancer. CA-125 level
were not a diagnostic tool to detect ovarian cancer, however it was useful to monitor the
progressive of disease and as a prognostic marker.
Objectives: The aim of this study is to prove whether CA-125 level before surgery in ovarian
cancer patients at Dr. Sardjito Hospital as well as a factor that correlates to the survival prognosis
of those patients.
Method: This research used cohort retrospective study at Dr. Sardjito Hospital Yogyakarta.
Results: As much as 71 ovarian cancer patients which had been included in this research with
inclusion and exclusion criteria. Subjects were divided into two groups. One group was for
patients with low CA-125 level (�35 U/ml) as much as 18 subjects and another group was for
patients with high CA-125 level (>35 U/ml) as much as 53 subjects. The result of a bivariate
analysis with an independent survival analysis (Cox�s Regression) was the stage of disease
(p=0.005, HR 4.827, CI 95% 1.623 � 14.355) and residual tumour (p=0.029, HR 2.605, CI 95%
1.101 � 6.161) were a survival prognosis factor. Multivariate analysis with a survival analysis
(Cox�s Regression) shows CA-125 level (p=0.031, HR 4.131, CI 95% 1.143 � 14.933) and
menarche (p=0.003, HR 4.989, CI 95% 1.736 � 14.342) were significantly related with survival
prognosis in EOC (Epithelial Ovarian Cancer) patients at Dr. Sardjito Hospital.
Conclusion: CA-125 level affects the survival rate of epithelial ovarian cancer patients in Dr.
Sardjito Hospital. Besides the level of CA-125, there are other factors that affect the survival rate
of epithelial ovarian cancer patients which is the stage of cancer, residual operation and age of
menarche.
Keywords: CA-125 level, EOC, prognosis, survival</description><publisher>[Yogyakarta] : Universitas Gadjah Mada</publisher><date>2014</date><type>Thesis:Thesis</type><type>PeerReview:NonPeerReviewed</type><identifier> , HERLINA PRAJATMO and , Dr. dr. H. Heru Pradjatmo, M.Kes, SpOG(K) (2014) HUBUNGAN KADAR CA-125 PRAOPERATIF TERHADAP PROGNOSIS SURVIVAL PENDERITA KANKER OVARIUM EPITELIAL DI RSUP DR. SARDJITO. UNSPECIFIED thesis, UNSPECIFIED. </identifier><relation>http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=77142</relation><recordID>134493</recordID></dc>
|
| format |
Thesis:Thesis Thesis PeerReview:NonPeerReviewed PeerReview |
| author |
, HERLINA PRAJATMO , Dr. dr. H. Heru Pradjatmo, M.Kes, SpOG(K) |
| title |
HUBUNGAN KADAR CA-125 PRAOPERATIF TERHADAP PROGNOSIS SURVIVAL PENDERITA KANKER OVARIUM EPITELIAL DI RSUP DR. SARDJITO |
| publisher |
[Yogyakarta] : Universitas Gadjah Mada |
| publishDate |
2014 |
| topic |
ETD |
| url |
https://repository.ugm.ac.id/134493/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=77142 |
| contents |
Background: CA-125 level increases in 50% of patients with stage I, 90% of patients with stage
II, 92% of patients with stage III and 94% of patients with stage IV ovarian cancer. CA-125 level
were not a diagnostic tool to detect ovarian cancer, however it was useful to monitor the
progressive of disease and as a prognostic marker.
Objectives: The aim of this study is to prove whether CA-125 level before surgery in ovarian
cancer patients at Dr. Sardjito Hospital as well as a factor that correlates to the survival prognosis
of those patients.
Method: This research used cohort retrospective study at Dr. Sardjito Hospital Yogyakarta.
Results: As much as 71 ovarian cancer patients which had been included in this research with
inclusion and exclusion criteria. Subjects were divided into two groups. One group was for
patients with low CA-125 level (�35 U/ml) as much as 18 subjects and another group was for
patients with high CA-125 level (>35 U/ml) as much as 53 subjects. The result of a bivariate
analysis with an independent survival analysis (Cox�s Regression) was the stage of disease
(p=0.005, HR 4.827, CI 95% 1.623 � 14.355) and residual tumour (p=0.029, HR 2.605, CI 95%
1.101 � 6.161) were a survival prognosis factor. Multivariate analysis with a survival analysis
(Cox�s Regression) shows CA-125 level (p=0.031, HR 4.131, CI 95% 1.143 � 14.933) and
menarche (p=0.003, HR 4.989, CI 95% 1.736 � 14.342) were significantly related with survival
prognosis in EOC (Epithelial Ovarian Cancer) patients at Dr. Sardjito Hospital.
Conclusion: CA-125 level affects the survival rate of epithelial ovarian cancer patients in Dr.
Sardjito Hospital. Besides the level of CA-125, there are other factors that affect the survival rate
of epithelial ovarian cancer patients which is the stage of cancer, residual operation and age of
menarche.
Keywords: CA-125 level, EOC, prognosis, survival |
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Universitas Gadjah Mada |
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DAERAH ISTIMEWA YOGYAKARTA |
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2016-09-14T18:35:05Z |
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