RISIKO FEBRILE NON-HEMOLYTIC TRANSFUSION REACTION PADA RESIPIEN TRANSFUSI THROMBOCYTE CONCENTRATE NON-LEUKODEPLETED
| Main Authors: | , Trinovia Andayaningsih, , dr. Teguh Triyono, M.Kes., Sp.PK(K). |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/134139/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=75141 |
Daftar Isi:
- There is a high trending use of platelet transfusions for treatment and prophylaxis of bleeding in patients with hematologic disorders and malignancies. The high frequent of using platelet transfusions are followed by increasing risk of transfusion reactions. Febrile non-hemolytic transfusion reaction (FNHTR) is an acute transfusion reactions most often occur in the thrombocyte concentrate (TC) transfusions. The incident of FNHTR is associated with the presence of pyrogenic cytokines such as: interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) accumulation in TC products. Accumulation of these cytokines is associated with the presence of leukocytes in the product and the duration of storage before transfusion. This study aimed to observe the relative risk of FNHTR in transfusion of non leukodepleted compared to pre storage leukodepleted TC. This was an observational study with prospective cohort design. Subjects were children aged 1 - � 18 years with indication of platelet transfusions in the children's ward Dr. Sardjito Hospital and met the inclusion and exclusion criteria. There were 54 patients who were devided into two groups. Twenty seven subjects recieved nonleukodepleted TC and the other twenty seven were transfused by pre storage leukodepleted TC. Both groups were measured for axilar temperature every 30 minutes just a moment before transfused until 2 hours post transfusion. Positive for FNHTR if subjects showed rising of his/her body temperature � 10C without any other clinical signs or laboratory test results of another acute transfusion reaction such as transfusion related acute lung injury (TRALI), allergic reaction, acute hemolytic, or acute bacterial infection. Leukocytes number in TC products were counted manually using Nageotte chamber. Statistical analysis by determining the significant limit of p value < 0,05 and the relative risk with 95% confident interval. We obtained the relative risk of FNHTR on non-leukodepleted TC was 4,85 (p < 0,001) and 95% CI (2,23-10,5). There were statisticaly significant difference of leucocyte number between non-leukodepleted and leukodepleted TC respectively