PERBANDINGAN PENURUNAN TEKANAN DARAH PASIEN HIPERTENSI SETELAH PEMBERIAN LISINOPRIL MALAM ATAU PAGI HARI
| Main Authors: | , Annisa Nadya Utami, , Prof. Dr. Lukman Hakim, M.Sc., Apt. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/133896/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74784 |
Daftar Isi:
- Lisinopril is drug choice for hypertension therapy that works by inhibiting the action of angiotensin-converting enzyme (ACE). In 2011, research about the effect of circadian rhythms on the renin-angiotensin system proves that the main target of anti-hypertensive therapy with lisinopril experienced a peak activation at night, at bedtime. This study aimed to compare the reduction in blood pressure among outpatients with hypertension that consume lisinopril in the morning and at bedtime. This study is a prospective cohort analytic study design. The data in this study is collected with interviews and secondary data based on the patient's medical record in the hospital Dr. Sardjito May-July 2014. Of the 26 patients who were taken in this study is hypertension outpatient (13 patients use of lisinopril in the morning and 13 patients use lisinopril at bedtime) with hypertension using lisinopril 10 mg daily in the treatment of hypertension during the first month, results obtained show a decrease systolic blood pressure at 13.00 ± 13.16 mmHg and diastolic mmHg at 6.23 ± 11.34 in patients that took lisinopril in the morning and for the bedtime consumed lisinopril, resulted in a decrease in systolic blood pressure at 12.23 ± 15.19 mmHg and diastolic by 6.62 ± 11.93 mmHg. Based on a independent sample t-test with 95% confidence level, the above results showed no significant difference (p> 0.05). Administration of lisinopril given once daily in the morning and at bedtime did not show any significant difference in blood pressure reduction in patients with hypertension in the outpatient pharmacy department of RSUP Dr. Sardjito. Keywords : Hypertension, Circadian Rhythm, Lisinopril, Chronotherapy