PERBANDINGAN UKURAN DROPLET EMULSI PROPOFOL 200 MG YANG DICAMPUR DENGAN LIDOKAIN 10 MG PADA SUHU YANG BERBEDA 6 JAM SETELAH PENCAMPURAN
| Main Authors: | , Dona Eriyadi Kanas P, , Dr. Calcarina FRW, Sp.An, KIC. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/133514/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74204 |
Daftar Isi:
- Background. Propofol (2,6-diisopropylphenol) has gained popularity as an anesthetic agent both for induction and maintenance of anesthesia. Propofol is formulated as a lipid macroemulsion containing soybean oil (100 mg/ml), lecithin (12 mg/ml), and glycerol (22,5 mg/ml). Pain on injection of propofol is a common problem. Lidocaine has been frequently added to propofol emulsion for alleviating pain on injection. Macroemulsion propofol thermodynamically unstable and degrades over time. Mixture of aquaous lidocaine with propofol emulsion leads to such instability, physically the droplet size enlargment. Enlargement of propofol droplet size decrease the release rate of propofol and propofol concentrations but increase the risk for fat embolism. Risk for fat embolism increased when droplet size exceeds the percentage of fat globule >5 m (PFAT5) population >0.05%. In clinical practice we used propofol lidocaine mixture frequently to reduce propofol induced pain. That`s mixture sometimes was stored in the refrigerator or at room temperature for further usage. The purpose of this study is to compare mean droplet size propofol 200 mg-lidocaine 10 mg mixture after storage procedure for 3 housr and 6 hours in the different temperature. Methods. This was a controlled trial study to compared Mean Droplet Size (MDS) of propofol 200 mg-lidocaine 10 mg mixture after storage procedure in refrigerator(2-4) 0 C and at room temperature (19-24) 0 C at 3 hours and 6 hours. There were 12 samples in each group. The droplet size was determined using microscope monitor. Measurement of droplet size was done manually. In each samples we measured 500 droplets. Data were analyzed by independent t test for the normal distribution and Man Whitney test for non normal ditribution. A value of p < 0.05 was considered to be statistically significant. Result. There was a difference MDS between propofol 200 mg-lidocaine 10 mg mixture that was stored in refrigerator (1.99±0.45) with at room temperature (2.18± 0,67) at 3 hours, statistically significant (p<0.05), and that was stored in refrigerator(2,84±0.93) with at room temperature (3.16±1,24) at 6 hours, statistically significant (p<0.05). PFAT5 population in refigerator storage procedure was 1,56% and at room temperatur was 5% at 6 hours. No evidence of macroscopic change was noted all of samples (n=12/100%).