NANOPARTIKEL ALGINAT-KITOSAN SEBAGAI SISTEM LEPAS LAMBAT KURKUMIN
| Main Authors: | , AGENG TRISNA SPP, , Dr. Dwi Siswanta, M. Eng. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/133436/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74104 |
Daftar Isi:
- Preparation of a curcumin slow release materials using alginate and chitosan and evaluation of their release properties have been done. The nanoparticles were prepared by ionotropic pre-gelation of alginate core and followed by polyelectrolyte complexation of chitosan. Curcumin was chosen as a model drug. Surface area, morphology and structure characterization of nanoparticles were investigated by scanning electron microscope (SEM), transmission electron microscope (TEM) and fourier transform infrared spectra (FTIR). The optimization was done in term of calcium and polymer concentration. The diameter of the nanoparticles was about 51 and 90 nm, they were suitable for uptake in capillary due to their nanosize range and high drug encapsulation efficiency was achieved ranging from 65-85%. Studies in vitro of the controlled release of curcumin were investigated in phosphate buffer saline (PBS) at pH 7.4. The results indicated that nanoparticles presented potential as a slow release system because they could stay long time into bloodstream and improve solubility of the drug. Key words: slow release, pre-gelation, nanoparticles, curcumin