ENKAPSULASI KURKUMIN DALAM NANOPARTIKEL KITOSANPEKTIN TERTAUT SILANG GLUTARALDEHIDA DAN STUDI PELEPASANNYA SECARA IN VITRO
| Main Authors: | , GRASIANTO, , Dr. Dwi Siswanta, M.Eng. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/133425/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74090 |
Daftar Isi:
- An investigation of encapsulation of curcumin into glutaraldehydecrosslinked chitosan-pectin nanoparticles and its in-vitro drug release study had been conducted in order to determine the effectiveness of the nanoparticles to release curcumin in the releasing media. The composition of the components that influenced the curcumin release including chitosan, pectin and glutaraldehyde was studied. Nanoparticles were prepared using coacervation method by mixing chitosan and pectin, each was disssolved in 1% acetic acid solution, then added glutaraldehyde as crosslinker to the mixed solution. The prepared nanoparticles were characterized by FTIR, TEM, SEM, and XRD. In vitro drug release study was conducted by dispersing nanoparticles in the PBS:etanol (60:40) for 6 hours. The concentration of curcumin was determined spectrophotometrically. The kinetic of the curcumin release was analyzed by the several models