PENGARUH PERBEDAAN FREKUENSI PEMBERIAN KAPTOPRIL TERHADAP PENURUNAN DAN TARGET TEKANAN DARAH KEJADIAN EFEK SAMPING DAN KUALITAS HIDUP PADAPASIEN HIPERTENSI DI PUSKESMAS BAMBANGLIPURO
| Main Authors: | , RAMA SAMARA B., , Prof. dr. Agung Endro Nugroho, M.Si., Apt. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/133420/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74083 |
Daftar Isi:
- BACKGROUND: Treatment of hypertension is usually projected to prevent morbidity and mortality due to hypertension. Captopril is an antihypertensive drug that is effective in lowering blood pressure. This study aimed to compare the efficacy and adverse reactions of the difference frequency of captopril on quality of life of patients with hypertension. METHODS : This study was performed using a prospective cohort with a blood pressure observed for 1 month after use of the drug as well as assessing the quality of life of patients with MINICHAL questionnaire. The subjects used by 80 out patients aged 18-65 years in the Puskesmas Bambanglipuro newly diagnosed hypertension by a doctors. RESULTS :On the use of captopril 12,5 mg average reduction of systolic blood pressure at a frequency 2 times daily for 24,05±10,39 mmHg and 3 times daily at 28.72±10,65 mmHg (P =0.055), while the average decrease in diastolic 2 times daily administration of 6,22±6,39 mmHg and diastolic on 3 times daily administration of 7.44±6,37 mmHg (P =0.385). Achievement of the target blood pressure at a frequency of 2 times daily as many as 15 people (37.5%) and at a frequency of 3 times daily as many as 10 people (25%) with a P value = 0,228. Adverse reaction (cough) occurs only in the captopril are taken 3 times daily as many as5 people (11.1%) (P =0.057). Improved quality of life in 12,5 mg captopril twice daily administration of 2 mental domain 4.50±3.17 and 6.25±3.81in the administration of 3 times a day (P =0.027), while the somatic domain to 2 times daily administration of 0.35±0.66 and 0.62±0.87 on giving 3 meals a day (P =0.046). CONCLUSION : There was no significant difference in the decrease in blood pressure and achievement of targets as well as adverse reactions (cough) between the two groups of frequency of administration. Improved quality of life is better on the usage frequency of 3 times daily. Keywords : Captopril, blood pressure, adverse reaction, quality of Life, questionnaires MINICHAL