HIGH SENSITIVITY C-REACTIVE PROTEIN DAN GLUKOSA SAAT MASUK RUMAH SAKIT SEBAGAI FAKTOR PROGNOSTIK PADA SINDROMA KORONER AKUT
| Main Authors: | , Anny Mariyani, , dr. Tri Ratnaningsih, Sp.PK(K), M.Kes |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/133152/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73709 |
Daftar Isi:
- Acute coronary syndrome (ACS) is a collection of clinical symptoms of coronary artery disease with thrombotic disorders that cause atherosclerosis basis atherom plaque. ACS diagnosis obtained from the clinical symptoms, electrocardiographic (ECG) and cardiac marker Troponin. Based on the pathophysiology of ACS, inflammation plays a role in all stages of atherosclerosis, including the initiation, growth, and complications of atherosclerotic plaque. Inflammation contributes important in acute atherogenesis and further atherothrombotic. C-reactive protein (CRP) is an acute phase reactant that is a marker of inflammation that is proaterogenic whose role in further atherothrombotic process. Extralesion and intralesional inflammatory can accelerate the evolution of atheroma and trigger acute events in ACS demonstrated through increased levels of highsensitivity CRP (hs-CRP). High-sensitivity CRP is a method of measuring CRP with lower levels of detection is 0.1 to 15.0 mg / L. Excessive inflammatory response system, the increase of CRP which in turn can mediate myocardial damage and cardiac complications. Glucose is one of the important mediators of the inflammatory response in both diabetic and non-diabetic. Stress hyperglycemia is a marker that is more directly related to the rate of acute myocardial damage, larger infarcts activates the sympathetic nervous and counter-regulatory hormone secretion further, causing further hyperglycemia exacerbates inflammation, potentially forming a cycle \"unbroken circle\", resulting in further damage to the cell membrane in ultimately lead to death. At high glucose levels cause up-regulation of CRP synthesis in macrophages. Increased hs-CRP and glucose is a prognostic factor of major adverse cardiac events (MACE) in ACS. This study is a prospective cohort study which aims to determine the prognostic value of hs-CRP and glucose on admission in patients with ACS in the ICCU Dr.Sardjito Yogyakarta Hospital with a MACE outcomes: death, reinfarction, cardiogenic shock, acute heart failure, ventricular tachycardia and fibrillation (VT/VF), urgent-percutaneous coronary intervention (PCI) were assessed during the 7 days of treatment. Examination of hs-CRP and glucose each with immunoturbidimetric and hexokinase-G6PD method. The results of prognostic value in the form of relative risk (RR).