EKSPRESI RESEPTOR FcÎ3II (CD32) MONOSIT PADA INFEKSI DENGUE PRIMER DAN SEKUNDER
| Main Authors: | , SHANTI IKA SARI, , dr. Umi Solekhah Intansari, M.Kes, Sp.PK(K) |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/130760/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=71189 |
Daftar Isi:
- Dengue infection is a major health problem in the world, including Indonesia. Clinical manifestations of dengue infection vary widely, from asymptomatic until dengue shock syndrome (DSS). Antibody-dependent enhancement (ADE) hypothesis which states that non-neutralizing antibodies in secondary dengue infection may enhance dengue infection via FcÎ3 receptors is still controversial. Clinical research shows that not all secondary infections manifest as DHF/DSS, but nearly all DHF/DSS cases are caused by a secondary infection. Allegedly expre ssion of FcÎ3 effect on this incident. This is an observational analytical study with a cross sectional design to determine the e xpression of FcÎ3RII (CD 32) monoc ytes in patien ts w ith primary and secondary dengue infection. CD32 of monocyte were measured using FACS Calibur with lyse no wash technique. Primary and secondary dengue infection was determined by IgM/IgG optical density ratio using ELISA capture method. The ratio of IgM/IgG â�¥ 1.2 con sidered as primary infection, w hi le the ratio < 1.2 were considered secondary infection. Twenty patients primary and 32 patients secondary in acute phase of dengue infection were partisipated in th is stu dy. Ex pression s of monoc ytesâ�� FcÎ3RII (CD 32) were significantly lower in primary than secondary dengue infection (187.825±31.584 vs 218.598±43.414 MFI