KAJIAN POTENSI ANTIFUNGAL SENYAWA FENANTROLIN 1 TERHADAP ISOLAT Candida sp RESISTEN TERBINAFIN DENGAN METODE MICROBROTH DILUTION
| Main Authors: | , WIWID SANTIKO, , dr. Titik Nuryastuti,Sp.MK. M.Si, Ph.D. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/128474/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68821 |
Daftar Isi:
- Background: Fungus Infection especially Candida sp isolate, have a high mortality and morbidity in the world and Indonesia. Terbinafine as antifungal known cause resistance. The compound 1,10-Phenantroline has successfully differentiated to Phenantroline-1, which known have antibacterial and antiplasmodial effects. 1- 10,Phenantroline proved and binds to the metal complex form metal-phen complexes that bind to transtition metal ions, such as Cu2+, Mn2+ and Ag2+ and potentially as antifungal. Objective: To determine the potential of antifungal effect and Minimum Inhibitory Concentration (MIC) antifungal activity of Phenantrolin-1 against resistant strains of Candida sp with Terbinafine. Methods: Design of this study is descriptive experimental, used Microbroth Dilution method. Phenantrolin 1 with a concentration of 25