SINTESIS TURUNAN KALKON DARI MIRISTISIN MINYAK PALA DAN UJI POTENSI SEBAGAI PENGHAMBAT UV-A
| Main Authors: | , Hery Muhamad Ansory, , Prof. Dr. Hardjono Sastrohamidjojo, |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/128364/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68705 |
Daftar Isi:
- The synthesis of 4,5-methylenedioxy-3-methoxy chalcone from nutmeg oil had been carried out. The elucidations of the products were performed by using GC, TLC scanner, FT-IR, and 1 H NMR spectrometer. The UV-A inhibition in-vitro test of product was determined using UV-Vis spectrophotometer. Isolation of the essential oil from nutmeg pulp, mace and nutmeg produced 0.75%, 4.77% and 6.62% contained 10.54%, 38.45% and 9.24% of myristicin, respectively. Isolation of myristicin from nutmeg essential oil was done by fractional distillation yielded 7.45% of myristicin. Isomerization of myristicin using KOH ethanol at 84 �C for eight hours produces isomiristisin 95.01% in yield. Oxidation of isomiristisin with KMnO4 in acidic conditions using tween 80 as micellar catalyst at < 40�C produced 4,5-methylenedioxy-3-methoxy benzaldehyde (49.53%). The condensation between 4,5-methylenedioxy-3-methoxy benzaldehyde with acetophenone in alkali conditions yielded 55.31% of 4,5-methylenedioxy-3-methoxy chalcone. The UV-A inhibition in-vitro test of 4,5-methylenedioxy-3-methoxy chalcone using UV-Vis spectrophotometer showed that it has �ultra� protection.