KORELASI ANTARA ASAM HYALURONAT DENGAN SKOR FIB-4 PADA PENDERITA HEPATITIS KRONIK DAN SIROSIS HATI
| Main Authors: | , Mohammad Septa Adiwanda Saputra, , dr. Neneng Ratnasari, Sp.PD-KGEH |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/128330/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68670 |
Daftar Isi:
- Cirrhosis of the liver is a journey final pathology of various diseases liver. World Health Organization ( WHO ) provides limits histology liver cirrhosis as the diffuse abnormality, marked fibrosis and normal liver changes shape to form abnormal nodules. Currently has developed assessment of liver fibrosis by non invasive examination and routine laboratory specialized laboratory that is based on examination scores and examination FIB - 4 plasma levels of hyaluronic acid. Many previous studies which concluded that a second examination proved to be able to assess the severity of fibrosis. So far there have not been studies linking between FIB- 4 with an examination of plasma levels of hyaluronic acid . This study was conducted to determine the correlation between plasma levels of hyaluronic acid with fibrosis assessment by FIB - 4 in patients with chronic hepatitis and liver cirrhosis. The method used in this study is cross-sectional. The study was conducted in the clinic and ward gastroenterohepatologi Medicine Hospital Dr . Sardjito. Inclusion criteria were patients with a diagnosis of chronic hepatitis and liver cirrhosis based on clinical criteria, laboratory and liver ultrasound, patients aged > 18 years, following the research and willing to approach approval. Exclusion criteria were the presence of osteoarthritis, rheumatoid arthritis, diabetes mellitus, malignancy, psoriasis, multiple sclerosis and sepsis. The mean plasma hyaluronic acid levels of patients with chronic hepatitis were 176 ± 10,27 Î1⁄4g / L and FIB-4 score of 1,8±1,61 whereas in patients with liver cirrhosis obtained mean plasma hyaluronic acid levels were 256 ± 18,84 Î1⁄4g / L and FIB-4 score was 5,7 ± 4,04. In the group of chronic hepatitis , there is no correlation between hyaluronic acid with FIB-4 score (r =0,005