Uji Potensi Antijamur Senyawa Fenantrolin 1 terhadap Strain Candida sp. Resisten Itrakonazol dan Ketokonazol dengan Metode Microbroth Dilution

Main Authors: , HILMA TSURAYYA I, , dr. Titik Nuryastuti M.Si, PhD
Format: Thesis NonPeerReviewed
Terbitan: [Yogyakarta] : Universitas Gadjah Mada , 2014
Subjects:
ETD
Online Access: https://repository.ugm.ac.id/128154/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68488
ctrlnum 128154
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>https://repository.ugm.ac.id/128154/</relation><title>Uji Potensi Antijamur Senyawa Fenantrolin 1 terhadap Strain Candida sp. Resisten Itrakonazol dan Ketokonazol dengan Metode Microbroth Dilution</title><creator>, HILMA TSURAYYA I</creator><creator>, dr. Titik Nuryastuti M.Si, PhD</creator><subject>ETD</subject><description>Background: Candidiasis is an opportunistic and endogenous infection of Candida sp. which often come against the immunocompromise host. Candidiasis become the most opportunistic infection in people with HIV/AIDS. Invasive candidiasis become the fourth highest nosocomial infection in the United States and other developed countries. Itraconazole and ketoconazole are antifungal agents that widely used for treatment of candidiasis. However, irrational use of antifungal treatment cause the appearance of strains of Candida sp. which resistant to itraconazole and ketoconazole. This resistance trigger the need for new antifungal agents which more effective. Phenantroline 1 compound is new compound derivated from 1,10- phenanthroline. 1,10-phenanthroline has been shown to have antifungal activity against Candida sp. There are no data of antifungal potention of phenantroline 1 compound against strain of Candida sp. which resistant to itraconazole and ketoconazole. Objective: The objective of this study is to determine the antifungal potention of phenanthroline 1 compounds and minimal inhibitory concentration of these compounds against strains of Candida sp. which resistant to itraconazole and ketoconazole. Method: This study was conducted with experimental descriptive design, using microbroth dilution method. Result: The antifungal potention of phenanthroline 1 compound against strain of Candida sp. which resistant to itraconazole and ketoconazole are indicated by minimal inhibitory concentration 3.175 &#xCE;&#xBC;g/ml. Conclusion: Phenanthroline 1 compound has antifungal potention against strain of Candida sp. which resistant to itraconazole and ketoconazole, but the mechanism of action is still unknown.</description><publisher>[Yogyakarta] : Universitas Gadjah Mada</publisher><date>2014</date><type>Thesis:Thesis</type><type>PeerReview:NonPeerReviewed</type><identifier> , HILMA TSURAYYA I and , dr. Titik Nuryastuti M.Si, PhD (2014) Uji Potensi Antijamur Senyawa Fenantrolin 1 terhadap Strain Candida sp. Resisten Itrakonazol dan Ketokonazol dengan Metode Microbroth Dilution. UNSPECIFIED thesis, UNSPECIFIED. </identifier><relation>http://etd.ugm.ac.id/index.php?mod=penelitian_detail&amp;sub=PenelitianDetail&amp;act=view&amp;typ=html&amp;buku_id=68488</relation><recordID>128154</recordID></dc>
format Thesis:Thesis
Thesis
PeerReview:NonPeerReviewed
PeerReview
author , HILMA TSURAYYA I
, dr. Titik Nuryastuti M.Si, PhD
title Uji Potensi Antijamur Senyawa Fenantrolin 1 terhadap Strain Candida sp. Resisten Itrakonazol dan Ketokonazol dengan Metode Microbroth Dilution
publisher [Yogyakarta] : Universitas Gadjah Mada
publishDate 2014
topic ETD
url https://repository.ugm.ac.id/128154/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68488
contents Background: Candidiasis is an opportunistic and endogenous infection of Candida sp. which often come against the immunocompromise host. Candidiasis become the most opportunistic infection in people with HIV/AIDS. Invasive candidiasis become the fourth highest nosocomial infection in the United States and other developed countries. Itraconazole and ketoconazole are antifungal agents that widely used for treatment of candidiasis. However, irrational use of antifungal treatment cause the appearance of strains of Candida sp. which resistant to itraconazole and ketoconazole. This resistance trigger the need for new antifungal agents which more effective. Phenantroline 1 compound is new compound derivated from 1,10- phenanthroline. 1,10-phenanthroline has been shown to have antifungal activity against Candida sp. There are no data of antifungal potention of phenantroline 1 compound against strain of Candida sp. which resistant to itraconazole and ketoconazole. Objective: The objective of this study is to determine the antifungal potention of phenanthroline 1 compounds and minimal inhibitory concentration of these compounds against strains of Candida sp. which resistant to itraconazole and ketoconazole. Method: This study was conducted with experimental descriptive design, using microbroth dilution method. Result: The antifungal potention of phenanthroline 1 compound against strain of Candida sp. which resistant to itraconazole and ketoconazole are indicated by minimal inhibitory concentration 3.175 Î1⁄4g/ml. Conclusion: Phenanthroline 1 compound has antifungal potention against strain of Candida sp. which resistant to itraconazole and ketoconazole, but the mechanism of action is still unknown.
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