LEPTIN GENE POLYMORPHISM IN ISCHEMIC STROKE PATIENTS WITH HYPERTENSION
| Main Authors: | , THAHRANYA APPALASAMY, , Dr. Med. dr. Indwiani Astuti |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/128115/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68446 |
Daftar Isi:
- Background: Various factors underlie the pathophysiology of ischemic stroke condition. Polymorphism of leptin gene was done to determine its role as a risk factor in ischemic stroke. Objective: The research investigates the role of leptin gene polymorphism as a risk factor for hypertension and ischemic stroke. Hypertension is one of the factor that may elicit a mechanism causing ischemic stroke. Method: Case control study was conducted on randomly selected blood samples of 42 cases and 42 controls. Cases were samples of ischemic stroke patients from RSUD dr Zainoel Abidin Banda Aceh whereas controls were samples from the healthy population in Banda Aceh. PCR were done to the DNA isolated from blood samples to study the polymorphism of microsatellite alleles of leptin gene. Correlation studies were done to identify the relationship between the variables. Results: The microsatellite leptin gene polymorphism was grouped into common (Class I/II) and uncommon (Class I/I, Class II/II) genotypes. Leptin gene polymorphism has no significant relationship with ischemic stroke (p=0.081). Hypertension too has no significant relationship with leptin gene polymorphism (p=0.076). It was found that common genotype has an odds ratio of 2.18 and 2.1 for ischemic stroke and hypertension respectively, thus positively associates itself with the two aforementioned variables. Conclusion: Microsatellite polymorphism of leptin gene is not a risk factor of ischemic stroke and hypertension among the Malay ethnic of Banda Aceh.