PROFILE OF BREAST CANCER PATIENTS IN TULIP INTEGRATED CANCER CLINIC, SARDJITO GENERAL HOSPITAL YOGYAKARTA IN YEAR 2007
| Main Authors: | , LIM YI WEN, , dr.Susanna Hilda Hutajulu, Sp.PD.,Ph.D. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/128005/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68328 |
Daftar Isi:
- Background : Breast cancer remains the most frequent cancer of women worldwide. It is a heterogeneous disease in terms of risk factors, disease presentation and response to treatment. Epidemiological data are required to assess the burden and profile of cancer and to plan and evaluate cancer control activities in the community. There is no nation-wide cancer registry in Indonesia. National Cancer Registry in Jakarta only have catchment population within Jakarta province thus does not comprehensively represents the cancer profile of Indonesian in general. Yogyakarta, an agricultural-based city may have different breast cancer profile from Jakarta, the national capital city. Objectives : To study the profile of breast cancer patients in Tulip integrated cancer clinic, Sardjito General Hospital, Yogyakarta in year 2007 including epidemiological data, baseline diagnostic characteristic and management, and overall survival and to compare the baseline clinic-pathological characteristic from other regional data. Methods : Study is conducted in retrospective descriptive design using consecutive sampling method. We assess Case Report Form which derived from the newly developed organ-specific cancer registration in the Tulip Integrated Cancer Clinic, Sardjito Teaching Hospital, Yogyakarta. Data of all breast cancer patients who had been admitted between 1st January and 31st December 2007 were retrieved.Patient of male sex, patients who were diagnosed with other cancers concurrently and sarcoma are excluded. Data are analyzed using IBM SPSS Statistics software. Results : Patients have a median age of 48 years. Most of the patients are from Central Java (92.4%). The most common diagnosis is node positive, stage 4 invasive ductal carcinoma-NOS type with moderate-to-poorly differentiated histological grade. Fifty-seven cases (22.5%) patient present with palpable tumor at first presentation. ER/PR negative is the most common phenotype (47.9%). Seventy point eight percent of patients have either ER or Her2 receptor being positive while another receptor being negative. Modified Radical Mastectomy is the most frequently used technique in surgical treatment of breast cancer patients (23.9%). Chemotherapy is mostly prescribed as adjuvant therapy (62.4%). Only 134 patients (42.5%) receive radiotherapy. Thirty-nine point six percents of breast cancer patients receives hormonal therapy, 129 of them receives Tamoxifen while only 2 receives newer Aromatase Inhibitor. Only 2 patients receive Herceptin-Targeted therapy. Conclusion : Profile of breast cancer patients follows a pattern similar to that of other developing countries with earlier peak age and advanced disease stage at presentation. The most common diagnosis is node positive Invasive Ductal Carcinoma, Non-specific type with moderate-to-poorly differentiated histological grade. Hospital based and population based cancer registry at the national level is required for evidence-based decision making in managerial level for development of hospital protocol in future clinical management as well as develop public health policy.