COMPARISON ANTITHYROID EFFECT BETWEEN ORAL ANTIHYPERTHYROIDISM GROUP (METHIMAZOLE AND PROPYLTHIOURACIL) BASED ON MEAN OF THYROID HORMONE LEVEL (FT�) IN PATIENTS WHO DIAGNOSED HYPERTHYROIDISM IN OUT-PATIENT CLINIC RSUP DR. SARDJITO
| Main Authors: | , NURUL IZZATI MOHD ZULKIFLI, , dr.Mohammad Robikhul Ikhsan, M.Kes., Sp.PD-KEMD. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/127933/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68249 |
Daftar Isi:
- Background: Since the antithyroid drugs was introduced, propylthiouracil (PTU) and methimazole (MMI) are widely used in treating hyperthyroidism. However less study were conducted to compare which of these antithyroid drug is better in reducing the FT� level. Objectives: The aim of this study is to compare which of these two oral antithyroid drugs (MMI or PTU) is better in reducing the FT� level after 30 days therapy. Method: This was a retrospective descriptive study using the data from medical records with code ICD 10. E05: Hyperthyroidism. The survey was conducted in Instalasi Rekam Medis, RSUP Dr. Sardjito, Yogyakarta. The data analysis was done in January 2014 using IBM SPSS 20. Result: The mean difference of FT� level after 30 days for both MMI and PTU is insignificant (p=0.15). However, MMI shows a greater decrease in reducing FT� level in the second month of therapy and a greater stability in maintaining FT� level when reaching the normal range. Meanwhile PTU shows a greater decrease in reducing FT� level in short course (30 days) therapy. Conclusion: There is no difference in reducing mean difference of FT� level after 30 days therapy between MMI and PTU group.