PENGARUH PEMBERIAN EKSTRAK ETER DAUN OCIMUM BASILICUM TERHADAP INDEKS ARTHRITIS TIKUS PUTIH YANG DIINDUKSI DENGAN COMPLETE FREUND�S ADJUVANT
| Main Authors: | , EMANUEL FELICIA, , dr. Setyo Purwono M.Kes., Sp. PD. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2014
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/127701/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=67971 |
Daftar Isi:
- Background : Ocimum basilicum or sweet basil is a plant with many benefits, easy to find and often used by Indonesian society. Its anti-inflammatory properties has been shown in acute inflammation. Thus far, the research on the effect of Ocimum basilicum against chronic inflammation has not yet conducted. One form of chronic inflammation is rheumatoid arthritis. Objective : To find out the effect of Ocimum basilicum leaves ether extract administration towards white rats� arthritis index that has been induced by Complete Freund�s Adjuvant (CFA). Methods : This study used 40 white wistar rats divided into 5 treatment groups equally. On the first and fourth week, the rats induced using CFA 0,05 ml. On the sixth until ninth week, the rats were given oral intervention daily. First, second, and third group get the Ocimum basilicum extract in dose range of 50 mg/ 2ml, 100 mg/2 ml, and 200 mg/2 ml. As control, fourth group get Na diclofenac 2 mg/2 ml and fifth group get 2 ml of Aquades. The arthritis index was evaluated every week. Arthritis index delta from before and after treatment was analyzed using Kruskal-wallis non parametric test and compared between groups using Mannwhitney non parametric test. Results revealed significant if p<0.05 and not significant if p>0.05. Results : There is no significant differences effect among three dose variance (p>0,05). Arthritis index average decline shown by dose I 0,91 ± 0,23 (p=0,011), dose II 1,03 ± 0,36 (p=0,007), and dose III 0,97 ± 0,25 (p=0,007) are significantly bigger than negative control group 0,50 ± 0,27. Arthritis index average decline shown by both dose I (p=0,003), dose II (p=0,031), and dose III (p=0,007) are significantly smaller than the positive control group 1,38 ± 0,23. Conclusion : Administration of 50 mg/2 ml, 100 mg/2 ml, and 200 mg/2 ml Ocimum basilicum leaves ether extract showed a decrease on white rats� arthritis index induced by Complete Freund�s Adjuvant (CFA). Keywords: Ocimum basilicum, Rheumatoid arthritis, Complete Freund�s Adjuvant, Arthritis index.