PERBANDINGAN EKSPRESI INTERLEUKIN-10 BERDASARKAN DERAJAT HISTOPATOLOGIK PERADANGAN MUKOSA GASTER GASTRITIS KRONIK DENGAN INFEKSI HELICOBACTER PYLORI
| Main Authors: | , Febie Chriestya, , dr. Neneng Ratnasari, Sp.PD-KGEH. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/126509/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=66735 |
Daftar Isi:
- The incidence of Helicobacter pylori infection in Indonesia is very high, but the degree of severity of gastritis and the risk of developing gastric cancer is extremely low. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is considered to play a strong role in determining the degree of severity of gastric mucosal inflammation due to H. pylori infection. Research on the role of IL-10 based on the degree of gastric mucosal inflammation due to H. pylori infection in Indonesian population is still limited. This study aims to determine the comparison of IL-10 expression based on the grade of histopathological inflammation of gastric mucosa in patients with H. pylori-infected chronic gastritis. This study is a retrospective study, the design of study is cross-sectional. The study will be conducted by examining the histopathological biopsy specimens of chronic dyspepsia patients (aged 18-80 years) who have undergone endoscopy at Dr. Sardjito Hospital. Samples will be excluded if based on patient�s medical record data, the patient is known to have a history of gastroesophageal-reflux disease, malignancy, autoimmune disease, renal failure and chronic liver disease. An independent t-test or a Mann-Whitney test will be used to assess the difference of IL-10 expression based on the degree of inflammation of the gastric mucosa, depends on the normality of data distribution accordingly. Confounding factors i.e. age, bacterial density and sampling location will be tested by linear regression analysis. Statistically significant difference will be stated as p < 0.05 and 95 % CI.