EVALUASI PENGGUNAAN DIHYDROARTEMISININ+PIPERAKUIN DAN PRIMAKUIN PADA PENGOBATAN MALARIA FALCIPARUM TANPA KOMPLIKASI DI KOTA SORONG PROVINSI PAPUA BARAT
| Main Authors: | , Mayland Yee Sewa, , Prof. Dr. Mustofa, M.Kes., Apt. |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/126176/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=66374 |
Daftar Isi:
- Malaria is a major health problem in the province of West Papua, especially in the city of Sorong. Artemisinin-based combination therapy is the antimalarial combination therapy with artemisinin derivative as one component of the combination. Artemisinin-based combination therapy used in the city of Sorong is a combination dihydroartemisinin-piperaquine and primaquine (DHP+PQ). Since the use starting in 2008, DHP+PQ has not been evaluated for use in the city of Sorong. The purpose of this study was to determine the efficacy and side effects of dihydoartemisinin-piperakuin and primaquine in the treatment of uncomplicated falciparum malaria in the city of Sorong West Papua province. This study is an observational study to compare the results of the examination before, during and after treatment. Case detection activities conducted by purposive sampling is to determine the sample with certain considerations are in accordance with the inclusion criteria. The study was conducted at the General Hospital Sorong Regency, Malawei health centers, and Remu health centers Sorong. Measuring the effectiveness of DHP + PQ is by counting the number of parasites and axilla temperature on day 1st (D1), day 2nd (D2), day 3th (D3), day 7th (D7), day 14th (D14), day 21th (D21), and day 28th (D28) according to the WHOâ��s protocol. Effectiveness of DHP+PQ characterized by the absence of parasitemia and axilla temperature â�¤ 37.5ÂoC on D28. The result showed that of the 55 cases of falciparum malaria, not found early treatment failure and late clinical failure. Found late parasitological failure in 3 (5,45%) patients so that the DHP + PQ has a 94,55% efficacy. Possible side effects caused by D HP + PQ include nausea (7,27%), vomiting (5,45%) and dizziness (5,45%).