UJI AKTIVITAS ANTIHIPERLIPIDEMIA DAN ANTIATEROSKLEROSIS KOMBINASI EKSTRAK TERPURIFIKASI HERBA SAMBILOTO (Andrographis paniculata (Burm.f.) Nees) DAN HERBA PEGAGAN (Centella asiatica (L.) Urban) PADA TIKUS DIABETES MELLITUS TIPE 2 RESISTEN INSULIN
| Main Authors: | , KYKY HERLYANTI, , Prof. Dr. Agung Endro.N, M.Si., Apt. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/123026/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63136 |
Daftar Isi:
- Insulin resistance is a common condition that is believed to play a major role in the pathogenesis of metabolic syndrome, obesity and type 2 diabetes mellitus, and heart disease. Development of insulin resistance associated with a particle size of very low density lipoprotein (VLDL), which are very large, the particle size of low density lipoprotein (LDL) particle size is small and highdensity lipoprotein (HDL) is small. In addition, levels of VLDL, intermediete density lipoprotein (IDL), LDL in the blood are high and low HDL levels increase the risk of insulin resistance. Do the research activity of purified reductase bitter herbs extract combination dose of 912.1 mg / kg and herb gotu kola dose of 300 mg / kg BW, bitter herbs dose of 651.5 mg / kg and herb gotu kola dose of 500 mg / kg BW, bitter herbs doses 390.9 mg / kg and herb gotu kola dosage 700 mg / kg BW, purified extract of bitter herbs with a single dose of 1303 mg / kg BW, purified extract of Centella asiatica herb with a single dose of 1000 mg / kg with the main parameters measured include quantitative data total cholesterol, triglycerides, LDL and HDL blood and histopathology of data atherosclerosis in mice aorta. Rat insulin-resistant type 2 diabetes mellitus was made by way of fructose 1,8 g / kg lard and 5 ml / 200g BB, as well as egg yolks 5% for 70 days. Giving a combination of purified extract of bitter herbs and gotu kola herbs, single purified extracts or metformin 45 mg / kg on day 71 to day 77 every day orally. Then measured their blood fat levels. The results obtained the data that combination of purified herbal extract bitter dose of 912.1 mg / kg and herb gotu kola dose of 300 mg / kg body weight is a combination that can lower cholesterol levels, triglycerides, raise HDL cholesterol levels and gotu kola herb 1000 mg/kg BW can lower LDL level with the highest percentage compared to the other dose combinations extract and purified extract of bitter herbs singly.