KORELASI KADAR ESTRADIOL DENGAN DENSITAS MAMOGRAFI BERDASARKAN STATUS MENOPAUSE PADA PASIEN KANKER PAYUDARA
| Main Authors: | , RATNA TRIASNAWATI, , dr. Lina Choridah, Sp. Rad. |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
|
| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/122856/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62965 |
Daftar Isi:
- Background: Estradiol is the most dominant and active derivate of estrogen, a steroid hormone that plays a role in breast development. Mammographic density reflects fibroglandular tissue�s proportion of breast�s total volume. High estrogen level and mammographic density are risk factors for breast cancer. The correlation of estrogen level and mammographic density is still unclear. Objective: The aim of this study is to identify the correlation between estradiol level and mammographic density based on menopausal status of breast cancer patients. The correlation of estradiol level and mammographic density to the other risk factors (age, body mass index (BMI), menarke, first time pregnancy, breastfeeding and family history) also been observed. Methods: This observational analytic study was conducted in cross-sectional design. Sampling process was done by consecutive method at Oncology clinic Kotabaru Yogyakarta from October to December 2012. Peripheral blood was taken at follicular phase of menstrual cycle to measure estradiol level by electrochemiluminescence immunoassay (ECLIA). Thresholding method was used to analyze mammographic density. All of the data was analyzed by Spearman correlation test. Result: From a total of 40 subject recruited in this study, the estradiol level were ranged from 5 to 233,30 pg/ml (mean 50.49 pg/ml) while breast density ranged from 9,68 to 87,93% (mean 52.21%). Statistical analysis showed that estradiol level did not significantly correlated with mammographic density in both premenopausal (r = 0.145, p = 0.541) and postmenopausal (r = -0.125, p = 0.599) breast cancer patients. Among several risk factors, the significant correlation only seen between BMI and mammographic density, both in premenopausal (r = -0.638, p = 0.002) and postmenopausal (r = -0.517, p = 0.020). Conclusions: Estradiol levels and mammographic density are independent risk factor for breast cancer. Mammographic density correlated with BMI, which higher BMI will show lower breast density in breast cancer patients.