POTENSI YOGHURT UBI JALAR UNGU (Ipomoea batatas (L.) Lamb.) DALAM MEMPERBAIKI KADAR HDL DAN LDL SERUM TIKUS SPRAGUE DAWLEY YANG DIBERI DIET TINGGI LEMAK
| Main Authors: | , DINA SEPTARI ANINDYAH, , Lily Arsanti, STP., MP |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/122179/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62278 |
Daftar Isi:
- Background: High level of LDL and low level of HDL in serum can increase the risk factors of cardiovascular disease (CVD). Purple sweet potato is one of the functional food which has low price, easily accessible, rich in nutrients and active compounds, has been reported to have hypocholesterolemic effect. Yoghurt as beverages that contain good bacterias also has hypocholesterolemic effect. So, processing purple sweet potato into yoghurt could optimize the effect. Objective: This study was conducted to see the effect of purple sweet potato yoghurt on serum LDL-cholesterol and HDL-cholesterol level in rats with high fat diet. Method: Quasi experimental study with pre-post test with control group design was used. This study used twenty five (25) male Sprague Dawley rats aged 2 months. In the beginning, all rats were randomized into 5 group. Control group (ST) was given only standard diet, Y2 (YUJU 2ml/day) , Y4 (YUJU 4 ml/day), SV (simvastatin 0,8 mg/day), Y4+SV (combination Y4 and SV). Rats had been adapted for a week, then given a high-fat diet for 2 weeks, and blood analysis was done (pretest). The treatment start from here for 4 weeks. Blood samples were colected and analyzed at 2nd week (midtest) and 4th week (postest). Result: The average of HDL and LDL level were not significantly different in all groups, both midtest and postest (p>0,05). A significant reduction occured on LDL (pre-posttest) level of Y4 (-32,65%), SV (-23,27%) and Y4+SV (-34%) group. The HDL level also decreas in all groups. The lowest and not significant reduction (p>0,05) were occured in the Y2 (-8,27%) and Y4 (-4,85%) groups, but the increase of HDL was shown in last-2 weeks by Y4 group (26%