STUDI TENTANG GAMBARAN HISTOLOGIS GINJAL DAN JANTUNG MENCIT TOKSOPLASMOSIS YANG DITERAPI DENGAN TOXOPLASMANUUR DAN INTERTRIM ® LA
| Main Authors: | , WANGI WIJI LINUWIH, , Prof. Dr. drh. Sri Hartati, SU. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/121154/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=61211 |
Daftar Isi:
- Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondiiwhich may transmitted through oocyst contained in cat feses, the cyst which is in meat that is not cooked properly, or transmitted transplasentally. Toxoplasmosis treatment generally use sulfa and pyrimethamine (the combination between sulfadiazine and pyrimethamine). The objective of this study was to determine the benefit of Toxoplasmanuur and Intertrim®LA for treatment of T.gondii with histological parameters change. This study used 20 mice which were divided into four treatment i.e., control, infection of T.gondii, infection of T.gondii treated by Toxoplasmanuur and infection of T.gondii treated by Intertrim®LA. Tachyzoite infection of T.gondii 1�103 was done by injected intraperitoneally on the first day. The treatment with Toxoplasmanuur 8 mg/mice/day for seven days in a row and Intertrim®LA 0,001 ml/mice/day for 20 days in a row. The mice were necropted, then the kidney and heart were taken from each mouce and made histopathology preparations. The examination based on histological alteration. The Toxoplasmanuur treatment 8 mg/mice/day showed the alteration in kidney in the form of congestion and atrophy of the heart muscle. The Intertrim®LA treatment reduced the heart and kidneys damage and prolonged the life of mice so it can be concluded that Intertrim®LA is more effective in the treatment of toxoplasmosis.