PENGARUH TOKSOPLASMA NUUR DAN INTERTRIM ® LA TERHADAP GAMBARAN HISTOLOGI HATI DAN OTAK MENCIT (Mus musculus) YANG DIINFEKSI Toxoplasma gondii
| Main Authors: | , DINA KARTIKA RIYANI, , drh. Dwi Priyowidodo, MP. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/121071/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=61122 |
Daftar Isi:
- Toxoplasmosis is a disease caused by Toxoplasma gondii. The parasite forms a cyst who settled in the tissues of the body such as the lungs, heart, brain, and skeletal muscle. Some drugs have been produced to treat toxoplasmosis, as example is Toksoplasma Nuur and Intertrim® LA. This research aims to know the influence of Toksoplasma Nuur and Intertrim® LA against the histopathology of liver and brain of mice that infected with Toxoplasma gondii strain RH 1x103. Twenty-one mice (Mus musculus) divided into 4 treatment groups, group I as a negative control, group II infected by Toxoplasma gondii as a positive control. Toxoplasma gondii infection Group III and given Toksoplasma Nuur peroral 0.4 ml 2 x/day doses 8 mg/mice, dispensing is done until all the mice are dead. Toxoplasma gondii infection Group IV and given Intertrim® LA peroral 0.2 ml 1 x/day doses 20 mg/kg, dispensing is done until day 17th, on the 22nd day of the mice are at euthanasia. Mice in the necropsy, liver and brain samples were taken for histopathology examination. Results of the research showed that the Toksoplasma Nuur cannot treat toksoplasmosis. It is proven by the death of mice that earlier and on the histopatology of liver occurring necrosis, degenerations and occur brain gliosis. On the granting of Intertrim® LA can treat toksoplasmosis dan can extend the vitality of mice that infected with Toxoplasma gondii strain RH (type I). In conclusion, toksoplasmosis can not be treated with Toksoplasma Nuur but Intertrim® LA can.