PERBEDAAN KETEBALAN LAPISAN SERABUT SARAF PERIPAPIL PADA PENDERITA DIABETES MELLITUS DENGAN DAN TANPA RETINOPATI DIABETIKA
| Main Authors: | , EDY WIBOWO, , dr. Hartono, SpM (K) |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/119800/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59805 |
Daftar Isi:
- Background : Diabetic retinopathy (DR) is one of the leading cause of blindness worldwide. Over the last few decades, its prevalence has dramatically increased due to the increased number of people with diabetes. Neuronal degeneration is one of key pathogenic manifestations of diabetes and often present at early stage of diabetes, including in the neuro-retina. Purpose : To investigate the peripapillary retinal nerve fiber layer (RNFL) thickness in persons with diabetes with or without DR Material and Methods : This was a cross sectional study. Diabetic persons who met the inclusion criteria were included. Detailed retinal examination were performed using indirect ophthalmoscopy and slit lamp biomicroscope. Two independent retinal specialist comfirmed the DR diagnosis, following the International Clinical Diabetic Retinopathy Disease Severity Scale, and categorized into DM without retinopathy and DR. Result : There were 75 eyes included in this study, 15 (20%) no DR, 15 (20%) mild NPDR, 23 (30,7 %) moderate NPDR, 27 (36 %) severe NPDR, and 15 (15 %) early PDR. The mean RNFL peripapil thickness across different DR category was 110.07 ± 24.44 for DM without retinopathy, 110.53 ± 32.4 for mild NPDR, 104.28 ± 3.38 for moderate NPDR, 110.97 ± 17.18 for severe NPDR, and 148.63 ± 8.92 for early PDR. The mean of RNPFL thickness in persons without DR was lower than those with DR (110.07 ± 24.44 vs. 115,31 ± 30.90), not statictically significant. Conclusion : The mean of RNPFL thickness in persons without DR was lower than those with DR, but not statictically significant.