OPTIMASI FORMULASI TABLET EKSTRAK SARANG SEMUT (Hydnophytum formicarum Jack) MENGGUNAKAN DESAIN FAKTORIAL
| Main Authors: | , SUGIYONO, , Prof. Dr. Achmad Fudholi, DEA., Apt, |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/119708/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59711 |
Daftar Isi:
- Hydnophytum formicarum Jack (sarang semut) is a medical plant used traditionally for its cardiovascular, antiinflamatory and antiparasitic effects and have been used for treatments of hepatitis, rheumatism and diarrhea. In order to produce tablets which physical characteristics fill the standard, a research of sarang semut extract tablet formulation has been carried out by using Avicel PH 102 as fillers-binder and Explotab material as disintegrant. This research was aimed to find out the influence of Avicel PH 102 and Explotab and their interaction to the hardness and disintegration time of sarang semut extract tablet. For that purpose, a factorial design with Avicel PH 102 in 20%-90% and Explotab in 2%-8% was used. Tablets were made by a direct compression method. Respons observed were the tablet hardness and disintegration time. Based on the data analyzed by Yate�s treatment and Anava test, the Avicel PH 102 significantly increased tablet hardness and disintegration time, while the Explotab reduced tablet hardness and disintegration time. Combination of Avicel PH 102 and the Explotab did not showed interaction to the tablet hardness and disintegration time.