STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV) MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3
| Main Authors: | , Anjar Purba Asmara, , Prof. Drs. Mudasir, M.Eng., Ph.D. |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/119421/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59422 |
Daftar Isi:
- QSAR studies has been done on derivatives of triazolopiperazine amide as inhibitors DPP IV enzyme that causes diabetes mellitus type 2. The studies was begun by modeling the structures of the derivatives of triazolopiperazine amide and calcutating the descriptors of QSAR by semiempirical AM1 and PM3 methods which are available on Hyperchem� program. QSAR analysis was done by multilinear regression method analysis which is available on SPSS� program using electronic and molecular parameters. The best QSAR equation model for method of semiempirical AM1: -log -log IC50 = 155.259 + (13.149*qC1) + (1692.869*qC9) + (1300.431*qC10) + (601.809*qO25) + (4.762*EH) n = 18