PERBEDAAN KADAR SERUM MATRIX METALLOPROTEINASE-9 PADA PASIEN SINDROM KORONER AKUT DENGAN DAN TANPA HIPERGLIKEMIA
| Main Authors: | , Agus Fitriyanto Achmad, , Dr. dr. Budi Yuli Setianto, SpPD-KKV, SpJP(K), |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/119365/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59362 |
Daftar Isi:
- Background. Hyperglycemic condition increases the risk of mortality and severity in acute coronary syndrome patients. Matrix metalloproteinase-9 is an extracellular matrix destructive enzyme, which play a role in atherosclerotic plaque wrapping lyse and cause plaque rupture leading to acute coronary syndromes. In patients with acute coronary syndromes found elevated levels of MMP-9. Purpose. This study aimed to determine differences in serum levels of MMP-9 acute coronary syndrome patients with and without hyperglycemia. Methods. The study design was cross-sectional study. Sampling was carried out in a sequence of ACS patients who were treated in the ICCU Dr Sardjito Yogyakarta. Measurement of MMP-9 and blood glucose done once before thrombolysis of venous blood. Data presented in the form of a descriptive analysis of the characteristics of the study subjects such as average and standard deviation levels of MMP-9 and blood glucose. To analyze the differences in the levels of MMP-9 between patients with and without hyperglycemia SKA using Student�s T Test. Figures significance was p < 0.05. Results. There are 72 subjects, consisting of 34 ACS patients with hyperglycemia and 38 ACS patients with hyperglycemia. The mean blood glucose levels there were significant differences between the ACS groups with hyperglycemia and without hyperglycemia (204.4 ± 92.16 vs. 108.93 ± 19.1, p = 0.00). The mean levels of MMP-9 in ACS patients with hyperglycemia was significantly higher than patients ACS without hyperglycemia (1574 ± 573.61 ng / mL vs. 1370 ± 573.66 ng / mL, p = 0.025) Conclusion. Levels of MMP-9 in ACS patients with hyperglycemia significantly higher than ACS patients without hyperglycemia.