RASIO PREVALENSI ALLOANTIBODI PADA PASIEN TRANSFUSI BERULANG DIBANDING TIDAK BERULANG
| Main Authors: | , Titien Budhiaty, , dr. Teguh Triyono, MKes, SpPK(K) |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/118923/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58901 |
Daftar Isi:
- Allogenic blood transfusion has potential effect to trigger the formation of alloantibody in the recipient due to blood group antigen differences between donor and recipient. Thalassemia, hemodialysis, and malignancies patients get anemic during their illness, therefore requiring repeated and multiple erythrocyte transfusions. This increases the risk of developing alloantibody. Previous studies found that alloantibody incidence varies from 4-60%. The adverse event due to alloantibody is hemolytic transfusion reactions or HDN. The purpose of this study was to determine the prevalence ratio of alloantibody in patients with repeated transfusion compared to non repeated transfusion. This study used cross-sectional design. The study subjects consisted of two groups: the group with risk factors, consisting of thalassemia, HD, and malignancies patients who received repeated transfusions, and the group with no risk factors, consisting of patients who received transfusion only in once period. A total of 72 subjects were included in this study, each group consisted of 36 subjects. Screening and identification of antibodies were done in both groups. Prevalence ratio is analyzed with chi-square test. Logistic regression is performed to analyze the influence of other factors that contribute to alloantibody formation such as sex, age, diagnose, number of transfusion and frequency of transfusion. The prevalence ratio of the alloantibody was expected to be more than 1 in order to provide evidence-based of the importance of pre-transfusion antibody screening especially in patients with repeated and multiple transfusion