KORELASI PARAMETER HEMATOLOGI ANEMIA DEFISIENSI BESI DENGAN KADAR HbA1C SEBAGAI PENANDA DIABETES MELLITUS Kajian pada Wanita Usia Subur
| Main Authors: | , KUSUMASTUTI, , dr. Tri Ratnaningsih, M.Kes, SpPK-K |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/118564/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58539 |
Daftar Isi:
- Hemoglobin A1c (HbA1c) is a product of irreversible non-enzymatic process on one or both of N-terminal valine of Î2-hemoglobin chain. Besides plasma glucose levels, some conditions can affect the level of HbA1c. One of them is iron deficiency anemia (IDA). Women of childbearing age have more risks to undergo IDA because of pregnancy, birth, regular menstruation, and diet. The aims of this study was to determine the difference of HbA1c levels in women of childbearing age with IDA and without IDA and to determine the correlation between the hematologic parameters of IDA and HbA1c levels. This study design is cross-sectional. Twenty-eight women of childbearing age with IDA and 36 healhty women were included in the study. The inclusion criteria included woman age 15-49 years old, still menstruate regularly, no history of histerectomy, no use of hematinic drugs, no history of DM or the use of anti diabetic drugs. The exclusion criteria were : pregnancy, bleeding, impaired renal function, hepatic cirrhosis, hemolytic anemia, hemoglobinopathy, folic acid deficiency, did not attend to DR Sardjito General Hospital Clinical Laboratory during study period in February-March 2012, anemia with etiology other than iron deficieny based on CRP and ferritin status, and fasting blood glucose levels >100 mg/dL. All subjects were tested for complete blood count and HbA1c. Subsequently mean difference test was conducted to HbA1c levels on IDA group versus non-IDA group. Correlation was also sought on hematologic parameters and HbA1c levels. The mean of HbA1c levels in IDA group is 5,51+0,31% which is significantly higher than non-IDA group mean of 5,34+0,04% (p=0,017). There is a negative correlation between HbA1c with hemoglobin, hematocrit, MCV, MCH and a positive correlation with RDW. Concern should be given on women of childbearing age with low hemoglobin levels when interpretated HbA1c results. Screening for IDA is deemed necessary to ensure interpretation of HbA1c determination especially to diagnose pre-diabetic state.