KADAR ENDOTELIN-1 SEBAGAI PREDIKTOR MORTALITAS DAN GAGAL JANTUNG PADA INFARK MIOKARDIAL AKUT
| Main Authors: | , Agus Widiyatmoko, dr, , Prof. dr. Bambang Irawan, Sp.PD-KKV, Sp.JP(K) |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2013
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/118056/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=51184 |
Daftar Isi:
- Acute myocardial infarction (AMI) is accompanied by metabolic and neurohormonal changes that may relate to the severity of illness and clinical outcomes. Rapidly advancing secretion of neurohormones by neuroendocrine . systems is a physiologicresponseto myocardialdamage in patientswith AMI in order to maintain a hemodynamic homeostasis. However, the over reactive responses of these hormones, e.g., vasoconstriction and tachycardia, resulted in catecholamine, which might be harmful to the patients. Considerable clinical evidence shows that increased neuroendocrine activity is detrimental to patients with clinical setting of AMI. Endothelin (ET)-l, a 21 amino acid residue peptide made by endothelial cells, is the most potent endogenous vasoconstrictor yet identified. It has been reported that circulating ET-I increases in the early hours after AMI. After AMI, higher and more prolonged elevations of this vasoconstrictor have been discovered in patients with a complicated clinical course and left ventricular failure, and have consequently been closely associated with increased mortality. However, the precise pathophysiologic effects of ET-I in AMI patients remain uncertain. The research aimed to identified plasma endothelin determinatton in myocardial infarction is related to subsequent survival and assessed whether plasma endothelin measurements provide additional prognostic information to that obtained to be associated with high mortality. Plasma endothelin determination was obtained from 120 patients on day 3 after documented myocardial infarction and was related to 30 days mortality. The predictive power of endothelin was analyzed for risk factors of mortality and heart failure after myocardial infarction in a Kaplan Meier Survival model.