PREDIKTOR PENGGUNAAN GASTROPROTECTIVE AGENT PADA PASIEN YANG MENGGUNAKAN OBAT ANTI-INFLAMASI NONSTEROID DI RSUP Dr. SARDJITO PERIODE TAHUN 2010
| Main Author: | INDRIANTO, ADY BAGUS |
|---|---|
| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2012
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/100892/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=57825 |
Daftar Isi:
- that is used to treat pain in patients of osteoarthritis (OA) and rheumatoid arthritis (RA). The use of NSAIDs can cause gastrointestinal side effects, to prevent that side effects, NSAIDs are prescribe with gastroprotective agent (GPA). The goal of this study is to determine the factors that are considered in the GPA prescribing by the doctors in patients who have risk factors for gastric disorder as a result of the use of NSAIDs. This study was an observational with cross sectional design. The methods to collect the data was an retrospective. The subjects were OA and RA (according to the hospital perspective) outpatient at RSUP Dr. Sardjito period January to December 2010, that comply the inclusion and exclusion criteria. The data included patient characteristics (gender, age, occupation, payment method, the primary diagnosis), prescribing of NSAID, prescribing of GPA, history of gastrointestinal disease, prescribing of corticosteroids, prescribing of antiplatelet. The Data were processed and analyzed in a descriptive quantitative. Statistical analyzed methods using chi-square, logistic regression with 95% Confidence Interval. The results showed some association between the predictor factors (women, patient age >= 65 years, prescribing of oxicam, prescribing of diclofenac sodium, prescribing of NSAIDs > 1 type, prescribing of NSAID concomitant with corticosteroids, prescribing of NSAID concomitant with antiplatelet, patients with history of gastrointestinal, prescribing of NSAIDs with >=3 months duration) with prescribing of gastroprotective agent. Patient with history of gastrointestinal were the most predictor factors influential, with OR (odds ratio)=3.6 (95% CI: 2.79 - 4.66). Patients with history of gastrointestinal (dyspepsia) obtained the highest OR {OR=4,29 (CI 95%: 3.23-5.7)}, which means when patients with history of dyspepsia prescribed NSAIDs had greater risk of 4.29 times to get GPA prescription than patients without a history of dyspepsia. Prescribing of NSAIDs > 1 DDD (defined daily dose) had p value = 0.777, which means there was no relationship between GPA prescription with NSAIDs > 1 DDD prescription.