PERBEDAAN KADAR CARBOXY TERMINAL PROPEPTIDE PROCOLLAGEN TIPE I (PIP) SERUM PADA PASIEN GAGAL JANTUNG AKIBAT HIPERTENSI
| Main Authors: | , Nurul Aini, , dr. Lucia Kris Dinarti, SpPD-SpJP (K), FIHA, |
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| Format: | Thesis NonPeerReviewed |
| Terbitan: |
[Yogyakarta] : Universitas Gadjah Mada
, 2012
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| Subjects: | |
| Online Access: |
https://repository.ugm.ac.id/100130/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56176 |
Daftar Isi:
- Arterial hypertension affects heart tissue composition which leads to structural remodeling of the myocardium. The imbalance between synthesis and degradation of type I collagen leading to myocardial fibrosis in a form of type I collagen fiber accumulation in the interstitial and perivascular myocardium. Collagen fiber accumulation reduces relaxation stage, diastolic suction, myocardial stiffness and diastolic disfunction which affects systolic disfunction leading to heart failure. Concentration of carboxy-terminal propeptide of procollagen type I (PIP) in peripheral blood is a synthesis index of type I collagen in HHD. Thus, the measurement of PIP is useful to monitor myocardial fibrosis stage in heart failure and to determine the therapeutic strategy that aims not only to reduce arterial pressure and left ventricular mass but also to prevent myocardial remodeling. This research aimed to determine difference PIP level in patients heart failure stage A, B, and C caused heart failure which is caused by hypertension. The serum consentration of PIP was measured by enzyme immunoassay. This research was a cross sectional research designed for cardiology policlinic�s outpatients at Dr Sardjito General Hospital Yogyakarta from August 2009 until the calculated sample number is fulfilled. One-way ANOVA was used to analyze the differences between the three groups of heart failure stages after being tested for the normality using Kolmogorov-smirnove normality test, if the result didn�t show a normal value, a non-parametric test would be undergone using Kruskal- Wallis test followed by Mann-Whitney U test. The differences considered as significant if p < 0.05 with confidence interval of 95%. The research was performed in 64 patients heart failure caused by hypertension consisted of 22 stage A, 19 stage B and 23 stage C. PIP mean levels of the group stage B 819.78 ± 91,03 ng/ml was higher compared stage A 808.47 ± 80.8 ng/ml and PIP mean levels stage C 852 ± 55.51 ng/ml was higher compared stage B. The PIP mean levels didn�t differ statistically significant (p=0.317). Conclution: There were no significant differences in serum level of PIP on the stage heart failure A, B and C.