EFFECT OF FREEZE THAWING TECHNIQUE AND GAMMA IRRADIATION TO RESORCINOL RELEASE FROM MATRIX OF POLYVINYL ALCOHOL
| Main Authors: | ., Erizal; Pusat Aplikasi Teknologi Isotop dan Radiasi (PATIR)-BATAN Jl. Lebak Bulus Raya No.49, Jakarta 12070, ., Darmawan; Pusat Aplikasi Teknologi Isotop dan Radiasi (PATIR)-BATAN Jl. Lebak Bulus Raya No.49, Jakarta 12070, A., Basril; Pusat Aplikasi Teknologi Isotop dan Radiasi (PATIR)-BATAN Jl. Lebak Bulus Raya No.49, Jakarta 12070, ., Sudirman; Pusat Teknologi Bahan Industri Nuklir (PTBIN)-BATAN Kawasan Puspiptek, Serpong 15431, Tangerang Selatan |
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| Other Authors: | BATAN |
| Format: | Article application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
BATAN
, 2013
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| Online Access: |
http://jurnal.batan.go.id/index.php/jsmi/article/view/849 |
Daftar Isi:
- Hydrogels are polymers with three-dimensional structure that useful to immobilize drugs as sustained release system. Immobilization of resorcinol in the polyvinyl alcohol hydrogel (PVA) is prepared by combination of freeze thawing (1-3 cycles) and gamma irradiation (10-30 Gy). The chemical structure of hydrogels was characterized by Fourier Transform- Infra Red (FT-IR) spectrophotometer. Gel fraction and water absorption were measured by gravimetry. The release of resorcinol was determined by Ultraviolet-Visible (UV-Vis) spectrophotometer. The results of evaluation showed that by increasing the number freeze-thawing up to 3 cycles and irradiation dose to 30 kGy, the gel fraction can reach up 95 %. In contrast, the water absorption of hydrogels decreases from 600 % to 200 %, and the decreasing release profile of water absorption of hydrogels (at the same condition) was similar with the release profile of resorcinol from 88 % to 59%. The combination of freeze-thawing and gamma irradiation can be considered as one of the immobilization techniques for sustained drug release.Keywords: PVA, Hydrogel, Resorcinol, Irradiation, Freezing thawing.