Optimizing combination of sambiloto herbal water fraction and salam leaf water fraction as anti-inflammation
| Main Authors: | Mustafa, Raymond Harris, Tamayanti, Wahyu Dewi, Hadisoewignyo, Lannie, Soegianto, Lisa, Ervina, Martha |
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| Format: | Proceeding PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Universitas Muhammadiyah Surakarta
, 2015
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| Subjects: | |
| Online Access: |
http://repository.wima.ac.id/4200/1/proceding%20ICB%20pharma.pdf http://repository.wima.ac.id/4200/ |
Daftar Isi:
- Sambiloto herbs and salam leaves, which are effective to reduce blood sugar level with different mechanism, have been suggested to produce a synergy as antioxidant and anti-inflammatory agent, hence the optimum combination formula is remained to be elaborated. By reducing blood sugar level and showing antioxidant, and anti-inflammatory activity, both plants were hypothesied of its ability ameliorating diabetes mellitus complexity. This study aimed to discover the optimal combination formula of sambiloto herbs and salam leaves water fraction to produce anti-inflammation effect. Carrageenan was used to induced the inflammatory condition. Optimization was conducted by factorial design utilizing 2 factors and 2 levels. Both factors, sambiloto herbs and salam leaves in the range of low level 1:10 and high level 10:1 with the used doses were 100 mg/kg BW at low level and 300 mg/kgBW for high level. The observed parameters were anti inflammaation potential percent and edema rate. Conclusively, this study proposed that optimum combination formula of sambiloto herbs: salam leaves water fraction = 1.14 : 9.87 with 234 mg dose. The combination formula was theoretically resulted the optimum anti inflammation potential percent of 45.68% and ER of 38.39% compared with other combination formulas.