Role of Natural Polysaccharides Xanthan GUM-Locust Bean Gum in Per-Oral Druc Delivery Systems
| Main Authors: | Hadisoewignyo, Lannie, Fudholi, Achmad |
|---|---|
| Format: | Proceeding PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2010
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| Subjects: | |
| Online Access: |
http://repository.ukwms.ac.id/id/eprint/25027/2/22pi-Role_of_natural_polysaccharides_.pdf http://repository.ukwms.ac.id/id/eprint/25027/13/29pi-R1%262-Role_of_natural_polysaccharides_.pdf http://repository.ukwms.ac.id/id/eprint/25027/1/22pi-Role_of_natural_polysaccharides_Hasil%20Cek%20Similarity.pdf http://repository.ukwms.ac.id/id/eprint/25027/ |
Daftar Isi:
- Xanthan gum is a heteropolysaccaride derived from corn starch and produced by fermentation with the bacteria Xanthomonas campestris. Locust bean gum is a natural hydrocolloid obtained from the seed endosperm of the carob tree (Ceratonia siliqua L.). The structure of locust bean gum consists of a β-(14)-D-mannosa backbone to which D-galactose units are attached α-(16). Locust bean gum is a non ionic polysaccaride, which can form gel if it is combined with xanthan gum Locust bean gum is capable of synergistic interactions with xanthan gum. This combination can be used for a matrix of a sustained release dosage form based on the ability of the combination of xanthan gum and locust bean gum to form gel. In this research, ibuprofen was used as an active ingredient formulated in control release tablet dosage form. The results exhibited that the combination of xanthan gum and locust bean gum at a ratio of 1:1 gave the longest in vitro release. Kinetic drug release tend to zero order with dominant mechanism is erosion.