Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement
| Main Authors: | Hartono, Sandy Budi, Hadisoewignyo, Lannie, Yang, Yanan, Meka, Anand Kumar, Antaresti, -, Yu, Chengzhong |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
IOP Publishing Ltd
, 2016
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| Subjects: | |
| Online Access: |
http://repository.ukwms.ac.id/id/eprint/24096/1/3-Amine_functionalized_cubic_.pdf http://repository.ukwms.ac.id/id/eprint/24096/13/2-R1%262-Amine_functionalized_cubic_.pdf http://repository.ukwms.ac.id/id/eprint/24096/7/3-Amine_functionalized_cubic_Hasil%20Cek%20Similarity.pdf https://doi.org/10.1088/0957-4484/27/50/505605 http://repository.ukwms.ac.id/id/eprint/24096/ https://iopscience.iop.org/article/10.1088/0957-4484/27/50/505605 |
Daftar Isi:
- In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100–200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur). The bioavailability of MSN-A-Cur and MSM-A-Cur was considerably higher than that of ‘free curcumin’. These results indicate promising features of amine functionalized MSN as a carrier to deliver low solubility drugs with improved bioavailability via the oral route.