In Vitro 5-LOX Inhibitory and Antioxidant Activities of Extracts and Compounds from the Aerial Parts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm
| Main Authors: | Wijaya, Sumi, Jin, Khoo Teng, Nee, Ting Kang, Wiart, Christophe |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Walter de Gruyter GmbH & Co. KG, Berlin/Boston
, 2012
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| Subjects: | |
| Online Access: |
http://repository.wima.ac.id/20126/1/3-In_vitro_5_LOX_inhibitory_.pdf http://repository.wima.ac.id/20126/ https://www.degruyter.com/view/j/jcim.2012.9.issue-1/1553-3840.1615/1553-3840.1615.xml?format=INT https://doi.org/10.1515/1553-3840.1615 |
Daftar Isi:
- The aim of this study was to investigate the antioxidant and anti-inflammatory potentials of crude extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. and its isolated compounds. Separation and structure elucidation of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. were conducted using chromatographic and spectroscopic method. The antioxidant activities of the extracts in this study were determined by the ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-carotene bleaching assays meanwhile the antiinflammatory activity was evaluated using the 5-lipoxygenase assay. Seven known compounds quercetin 3-O-glucoside (1), naringenin 7-O-glucoside (2), seneciphylline-O-glucoside (3), chrysoeriol (4), retrorsine (5), adonifiline (6) and 5,4′-di-O-methyl alpinumisoflavone (7) were isolated from ethanol extract of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. The ethanol and water extracts of Lopholaena coriifolia (Sond.) E. Phillips & C.A. Sm. elicited potent antioxidant and anti-inflammatory properties. Amongst the isolated compounds quercetin 3-Oglucoside gave strong antioxidant activity and adonifiline strongly inhibited 5-lipoxygenase activity.