Antioxidant, Anti-Inflammatory, Cytotoxicity and Cytoprotection Activities of Crassocephalum Crepidioides (Benth.) S. Moore. Extracts and Its Phytochemical Composition
| Main Authors: | Wijaya, Sumi, Nee, Ting Kang, Jin, Khoo Teng, Din, Wardah Mustafa, Wiart, Christophe |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
EuroJournals Publishing
, 2011
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| Subjects: | |
| Online Access: |
http://repository.wima.ac.id/20125/1/2-Antioxidant_anti-inflammatory_.pdf http://repository.wima.ac.id/20125/ https://www.researchgate.net/publication/263582229_Antioxidant_Anti-Inflammatory_Cytotoxicity_and_Cytoprotection_Activities_of_Crassocephalum_Crepidioides_Benth_S_Moore_Extracts_and_Its_Phytochemical_Composition |
Daftar Isi:
- The hexane, ethyl acetate, ethanol and water extracts of Crassocephalum crepidioides (Benth.) S. Moore. were assessed for their antioxidant, anti-inflammatory, cytoxicity and cytoprotective activities. The ethanol extract displayed profound antioxidant activities and inhibited the enzymatic activity of 5-lipoxygenase (5-LOX). The ethanol extract of Crassocephalum crepidioides (Benth.) S. Moore. at a concentration of 100 μg/ml, was non-toxic against MRC-5 and HepG2 cell lines. At the concentration of 25 μg/ml it gave a percentage of cytoprotection with the value of 69.47%. Phytochemical analysis of the ethanol extract revealed the presence of phenols and flavonoids with 422.22 gallic acid equivalent (mg/g) and 3.46 quercetin equivalent (mg/g). Phenolic compounds and flavonoids impart to Crassocephalum crepidioides (Benth.) S. Moore. its biological properties.