Influence of various concentrations of PVP K-30 as a binder on the physical quality of cerme (Phyllanthus acidus) leaves extract tablet
| Main Authors: | Foe, Kuncoro, Widodo, Teguh, Selfiani, Juleiny |
|---|---|
| Format: | BookSection PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Universitas Jendral Soedirman
, 2012
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| Subjects: | |
| Online Access: |
http://repository.wima.ac.id/14468/1/ICOMP%20UNSOED%202012-2.pdf http://repository.wima.ac.id/14468/ |
Daftar Isi:
- A Study on the influence of tablet formulae containing cerme leaves extract using PVP K-30 as a binder in the concentrations of 2% (formula A), 3% (formula B), 4% (formula C) on the physical quality of tablet has been conducted. Cerme leaves extract was obtained by percolation method employing ethanol 96% as a solvent. Tablets were prepared by wet granulation method and the physical quality of resulting granules was evaluated including moisture content, repose angle, flow rate, and compressibility. Granules were then compressed to yield tablets of 650 mg. in which each tablet contains 449 mg of dry extract of cerme leaves. The physical quality of resulting tablets was evaluated including weight uniformities, hardness, Friability, disintegration time, dissolution, and a comparative qualitative determination of chemical contents of cerme leaves extract by TLC (Thin Layer Chromatography) in various samples commencing from viscous extract until tablet dosage form. The hardness, friability, disintegration time. and dissolution data were evaluated using completely randomized design ANOVA with a level of confidence of 95% and subsequently followed by LSD (Least Significant Difference) test. It can be concluded that cerme leaves extract could be formulated as a tablet and met the physical quality requirements of tablet. There no significant differences on the hardness and dissolution of three formulae tablets (Fcalc < Ftable). On the other hand. The friability and disintegration time of three formulae tablets differed significantly (Fcalc < Ftable). Formula A was the selected one owing ot its shortest disintegration time and highest economic value (least binder concentration).