Effect Metformin on Superoxide Dismutase and Nuclear Factor Kappa Beta in Diabetes Patient with Tuberculosis Infection
| Main Author: | Novita,, Bernadette Dian |
|---|---|
| Format: | Proceeding NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2015
|
| Subjects: | |
| Online Access: |
http://repository.wima.ac.id/14454/1/IDF.pdf http://repository.wima.ac.id/14454/ https://www.idf.org/WorldDiabetesCongress2015/data/HtmlApp/main.html# |
Daftar Isi:
- Metformin (MET) has possibilities of utilizing as a combination drug with existing antibiotics for TB therapy and controlling the growth of drug-resistant Mycobacterium tuberculosis strains via production of mitochondrial reactive oxygen species and facilitates phagosome-lysosome fusion. MET whom given to type 2 DM newly TB co-infection patients were improved the SOD’s level and inhibited of NF-ĸβ activation. The clinical effect, especially smear reversion, during metformin applied with anti-tuberculosis and insulin in patients with type 2 DM newly TB co-infection were remain unknown, and this result contributes much to our understanding the use of MET in type 2 DM-TB co-infection management.