Antidiabetic Properties Of Andrographis Paniculata Nees And Eugenia Polyantha Wight Leaves In Wistar Rats By Oral Glucose Tolerance Test
| Main Authors: | Widharna, Ratna Megawati, Ferawati, ., Hendriati, Lucia, Surjadhana, Adrianta, Jonosewojo, Arijanto, Widjajakusuma, Elisabeth Catherina |
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| Format: | Proceeding PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2010
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| Subjects: | |
| Online Access: |
http://repository.wima.ac.id/1099/1/PROCEEDING%20POKJANAS%20TOI%2039%20Ratna-Megawati.pdf http://repository.wima.ac.id/1099/ |
Daftar Isi:
- Ethanol and water extract of Andrographis paniculata Nees, and ethanol extract of Eugenia polyantha Wight leaves were evaluated for their hypoglycemic effects in healthy albino Wistar rats by oral glucose tolerance test. Both ethanol extract of Euginia polyantha (200 mg/kg bw) and water extract of Andrographis paniculata (200 mg/kg bw) showed significant increase of blood glucose level at T30 and T60 (T30 = 30 minutes after glucose loading or 60 minutes after drugs administration, T60 = 60 minutes after glucose loading or 90 minutes after drugs administration). Meanwhile, ethanol extract of Andrographis paniculata (200 mg/kg bw) showed significant increased in blood glucose level up to T90. Therefore, water extract of Andrographis paniculata (200 mg/kg bb) was considered faster to lower blood glucose level than the ethanol extract at the same dose of administration. Furthermore, water extract of Andrographis paniculata and Euginia polyantha leaves could be selected for further research as they reduce the blood glucose level steadily and does not cause hypoglycemia such as in glibenclamide.