Synthesis and cytotoxic activity of N-(2,4-dichloro)benzoyl-N’- phenylthiourea against human breast cancer cell line
| Main Authors: | Kesuma, Dini, Putra, Galih Satrio, Yuniarta, Tegar Achsendo |
|---|---|
| Format: | Article PeerReviewed application/pdf |
| Bahasa: | eng |
| Terbitan: |
the Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
, 2022
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| Subjects: | |
| Online Access: |
http://repository.ubaya.ac.id/41960/ http://www.tjps.pharm.chula.ac.th/ojs/index.php/tjps/article/view/697 |
Daftar Isi:
- Introduction: Urea- and thiourea-based compound has shown a potency to be further developed as anticancer compound. Objective: Another novel phenylthiourea analog (N-(2,4-dichloro)benzoyl-N’-phenylthiourea) was synthesized through Schotten-Baumann reaction followed by the assessment of its cytotoxic activity. Methods: N-(2,4-dichloro)benzoyl-N’-phenylthiourea was synthesized using N-Phenylthiourea and 2,4-dichlorobenzoyl chloride as starting materials. The reaction started at low temperature for 30 min followed by reflux for 8 h to yield target compound. Cytotoxicity assay was then performed against MCF-7, T47D, and Vero normal cell line. Results: The compound has been synthesized and its structure has been verified using infrared, 1H-nuclear magnetic resonance (NMR), 13C-NMR, various 2D NMR, and mass spectra. Furthermore, it is shown that the synthesized compound possesses better cytotoxicity profile than hydroxyurea. Conclusion: N-(2,4-dichloro)benzoyl-N’-phenylthiourea is a potential thiourea analog as anticancer agent, albeit further research is needed.